Oral Applications

Typically, tablets or capsules are used to deliver greater than 90% of pharmaceuticals to patients. Factors that affect the efficacy of a drug include the solubility, bioavailability, biological half-life, dose and dosing regimen, and shelf-life, as well patient factors including diet and health condition. Technologies that can improve oral delivery of drugs by controlling the release and absorption in the GI tract are in great demand, and improved powder processing is one strategy that can overcome these obstacles. In vivo studies have shown that sustained-release and improved bioavailability of pressed powders for improved tablet processing of next generation pharmaceuticals.

Nanotherapeutics particle delivery systems are able to:

• Improve the oral bioavailability of insoluble and poorly absorbed drugs that require injection (antibiotics, antivirals, anti-inflammatories, and nutritionals).
  

• Enable oral delivery of macromolecules (peptide/protein).
  

• Provide pharmaceutical life-cycle management opportunities.