NanoCOAT™

The NanoCOAT™ process is a patented solventless-microencapsulation system for coating micron and sub-micron size powders. A core nanoparticle/microparticle is encapsulated with a thin layer of a coating material, such as a surfactant or a biodegradable polymer. The coating may be applied to slow the rate of release of an active component, improve the dispersion/flow properties into the lung or nasal cavity, or increase the absorption into systemic circulation.

In addition, the NanoCOAT™ process has been shown to reduce moisture uptake in stability tests beyond a year, thus improving the shelf-life and reducing the degradation of peptides and proteins through the amorphous to crystalline transition. Because of the low excipient load and ease of manufacturing, NanoCOAT™ also offers an alternative over reformulating to get improved drug products into clinical trials more quickly.

Advantages of this process include the ability to control drug release kinetics, for use with a broad variety of coating materials, to dramatically reduce the polymer load compared to traditional polymeric microspheres, and to provide cost-effective and rapid manufacturing under sterile cGMP conditions.